It depends on whether you have FRAM-RTC installed. If you have FRAM-RTC then you can use SAVE_EEP to save to any of the 11K words of FRAM space and you don't have to execute SETSYSTEM 252, 0. Also A to Z, A$ to Z$ and DM[] can be made non-volatile by turning on DIP switch #1.
If you don't have FRAM-RTC then you still can save some constant to the EEPROM using the SAVE_EEP but you need to execute SETSYSTEM 252, in order to permanently save the data to flash memory. A to Z, A$ to Z$ and DM[] in this case ARE VOLATILE and DIP switch #1 will have no effect. Please read Chapter 1 of the FMD User Manual for detailed explanation on this topic.